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What is occurring during ventricular ejection?


A) The AV and semilunar valves are closed as ventricular pressure is increasing.
B) The AV valves are open and the semilunar valves are closed as ventricular pressure is. increasing
C) The AV and semilunar valves are open as blood is leaving the ventricles.
D) The AV valves are open and the semilunar valves are closed as blood is leaving the ventricles.
E) The AV valves are closed and the semilunar valves are open as blood is leaving the ventricles.

F) A) and B)
G) None of the above

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Contractile activity of cardiac muscle is neurogenic

A) True
B) False

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Which of the following is NOT a part of the excitation- contraction coupling in cardiac muscle?


A) An action potential travels along transverse tubules.
B) Calcium binds to calmodulin in the cytosol.
C) Calcium channels in the sarcoplasmic reticulum open, allowing calcium ions to enter the cytosol.
D) Calcium channels in the plasma membrane open, allowing calcium ions to enter the cell.
E) Calcium opens calcium channels in the sarcoplasmic reticulum.

F) A) and E)
G) D) and E)

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Ejection of blood from the right ventricle will continue until


A) pressure in the pulmonary artery is less than pressure in the right ventricle.
B) pressure in the aorta is greater than pressure in the right ventricle.
C) pressure in the pulmonary artery is greater than pressure in the right ventricle.
D) the pulmonary semilunar valve contracts, inducing closure.
E) pressure in the aorta is less than pressure in the right ventricle.

F) A) and D)
G) A) and E)

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The depolarization of the action potential in the pacemaker cells is driven by the rapid influx of ions through channels.


A) potassium : funny
B) sodium : funny
C) potassium : T- type calcium
D) sodium : T- type calcium
E) calcium : L- type calcium

F) B) and C)
G) All of the above

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In an ECG recording, the RR interval is 0.5 seconds. What is the heart rate?


A) 30 beats/min
B) 120 beats/min
C) 60 beats/min
D) 100 beats/min
E) 50 beats/min

F) A) and B)
G) B) and E)

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John has aged gracefully now at the age of 75 with distinguished gray hair and beard, unfortunately his SA node has failed and his heart rate is down to 40 beats per minute. An ECG shows bradycardia and his stroke volume is calculated to be 80 mL. John is short of breath and has low blood pressure and is feeling quite unwell. John's brother Jim is 78 years old and was a triathlete for many years and still swims and bikes five days a week. Jim's resting heart rate is 50 beats per minute and he feels great. His stroke volume has been calculated to be 120 mL per beat. Calculate the cardiac output for both John and Jim and explain why Jim feels so much better than John.

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CO = SV × HR. John's CO = 80 × 40 = 3200...

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Which of the following variables is NOT involved in determining ventricular preload?


A) atrial pressure
B) venous return
C) afterload
D) filling time
E) central venous pressure

F) A) and B)
G) C) and D)

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The increase in ventricular volume early in diastole reflects the


A) back- flow of blood from the aorta.
B) relaxation of the ventricle.
C) contraction of the atria moving blood into the ventricle.
D) passive movement of blood through the atrium and into the ventricle.
E) increased stiffness of the heart.

F) B) and C)
G) B) and D)

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Which statement best describes why atrial depolarization is usually not detected on a normal ECG?


A) The electrodes cannot be placed high enough on the chest to detect the atria.
B) The atria do not contract only the AV valves open.
C) The voltage change in the atria is minimal and therefore does not register on an ECG.
D) It occurs at the same time as the QRS complex.
E) The atria are so small and the depolarization happens so quickly that it cannot be detected.

F) All of the above
G) C) and E)

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In what phase is the cardiac cycle when all four valves are closed and pressure in the ventricle is decreasing?


A) atrial contraction
B) ventricular filling
C) isovolumetric contraction
D) isovolumetric relaxation
E) ventricular ejection

F) B) and C)
G) None of the above

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Abnormal electrical activity of the heart is called myocardial infarction.

A) True
B) False

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If both the SA node and the AV node fail, what would be the expected outcome of impulse rate within the heart?


A) The heart is autorhythmic therefore it continually beats even after death because death is defined as a lack of brain waves.
B) The sympathetic nervous system takes over and maintains normal heart rate.
C) The vagus nerve takes over and maintains a normal heart rate.
D) The rate would be 30- 40 beats per minute due to the concentration of pacemaker cells in the Purkinje fibers.
E) The individual would be in heart failure or have a myocardial infarction due to the lack of a beating heart.

F) B) and D)
G) B) and C)

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The term autorhythmicity refers to the heart's ability to


A) generate its own contractile cycle.
B) intrinsically modify its contractility.
C) originate its contraction neurogenically.
D) act as a functional syncytium.
E) conduct action potentials along the conduction pathway.

F) All of the above
G) A) and E)

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During which phase of the cardiac cycle are all four heart valves open?


A) isovolumetric relaxation
B) isovolumetric contraction
C) ventricular filling
D) ventricular ejection
E) none

F) A) and B)
G) D) and E)

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Which channel type allows ion movement out of the cell during repolarization of the autorhythmic cells?


A) potassium channels
B) T- type calcium channels
C) funny channels
D) L- type calcium channels
E) voltage- gated sodium channels

F) A) and B)
G) None of the above

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During isovolumetric relaxation,


A) the AV and semilunar valves are closed and ventricular pressure is increasing.
B) the AV valves are open, the semilunar valves are closed, and ventricular pressure is decreasing.
C) the AV and semilunar valves are closed and ventricular pressure is decreasing.
D) the AV and semilunar valves are open and ventricular pressure is decreasing.
E) the AV and semilunar valves are open and ventricular pressure is increasing.

F) B) and E)
G) B) and D)

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What are the three layers of the heart, from inside to outside?


A) epicardium, myocardium, and endothelium
B) endothelium, epicardium, and myocardium
C) endothelium, myocardium, and epicardium
D) myocardium, epicardium, and endothelium
E) myocardium, endothelium, and epicardium

F) A) and D)
G) A) and B)

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In what phase is the cardiac cycle when the semilunar valves are open and AV valves are closed?


A) atrial contraction
B) ventricular filling
C) isovolumetric contraction
D) isovolumetric relaxation
E) ventricular ejection

F) B) and E)
G) None of the above

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Which of the following is responsible for the rapid depolarization phase of an action potential within the pacemaker cells?


A) a decrease in PNa
B) an increase in PNa
C) an increase in PCa
D) an increase in PK
E) a decrease in PK

F) None of the above
G) All of the above

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